Assignment of the <i>Equus caballus</i> interleukin 8 gene <i>(IL8)</i> to chromosome 3q14.2→q14.3 by in situ hybridization

Assignment of the bovine attractin (ATRN) gene to chromosome 13q21q22 by in situ hybridization.

Attractin (ATRN, mahogany) is a gene involved in the regulation of pigmentation, body weight regulation and formation of the central nervous system in mammals (Gunn et al., 2001; He et al., 2001). Moreover, a soluble form of attractin found in humans is implicated in monocyte spreading and T-cell clustering (Duke-Cohan et al., 1998). In mice Atrn was mapped to MMU2, 73.9 cM (www.informatics.jax...

Assignment of maltase glucoamylase (MGAM) gene to bovine chromosome 4q34 by in situ hybridization and confirmation by radiation hybrid mapping.

In mammals, hydrolysis of the nonreducing ends of oligosacharide chains is carried out by an enzyme complex involving sucrase-isomaltase and maltase-glucoamylase which is anchored in the mucosa of the small intestine brush border (Semenza and Aurichino, 1989). It has been hypothesized that the human MGAM activity is an alternate pathway for starch digestion when luminal ·-amylase activity is re...

Assignment of the PHACTR1 gene to bovine chromosome 23q24 by fluorescence in situ hybridization and radiation hybrid mapping.

The phosphatase and actin regulator (PHACTR) proteins represent a family of protein phosphatase 1 (PP1) and actin regulatory proteins. PP1 is a multifunctional enzyme with diverse roles in the nervous system, including regulation of synaptic activity and dendritic morphology. In rat the Phactr1 gene was cloned for the first time as the prototypical member of this family (Allen et al., 2004). By...

Assignment of the human protein tyrosine phosphatase epsilon (PTPRE) gene to chromosome 10q26 by fluorescence in situ hybridization.

Assignment of the ovine uroporphyrinogen decarboxylase (UROD) gene to chromosome 1p34 --> p36 by fluorescence in situ hybridization.

Heme biosynthesis is a complex multistep process, taking place partly in the cytosol and partly in the mitochondria. A dysfunction of one or more enzymes in the biochemical pathway results in the accumulation of intermediates of the porphyrin synthesis and to the onset of porphyrias. Porphyrias are mainly hereditary; however, they can also be induced by exogenous factors. Depending on which enz...